2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Aurora Kinases-IN-2

Aurora Kinases-IN-2 (compound 12Aj) 是一种有效的 Aurora 激酶抑制剂 (Aurora kinases)，对 Aurora A 和 Aurora B 的 IC50 值分别为 90 和 152 nM。Aurora Kinases-IN-2 通过调节细胞周期蛋白 B1 和 cdc2 将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 可用于癌症研究。

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Aurora Kinases-IN-2 Chemical Structure

Aurora Kinases-IN-2 Chemical Structure

CAS No. : 2241914-86-1

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Aurora Kinases-IN-2 相关抗体

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Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].

IC50 & Target[1]

Aurora A

90 nM (IC50)

Aurora B

152 nM (IC50)

体外研究
(In Vitro)

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aurora Kinases-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 1, 5 and 10 μM
Incubation Time: 24 hours
Result: Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.
分子量

435.86

Formula

C22H18ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aurora Kinases-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora Kinases-IN-22241914-86-1Aurora Kinaseanti-tumoraurora kinasepyrazinescell cycleInhibitorinhibitorinhibit

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