2. Anti-infection
  3. SARS-CoV
  4. AVI-4206

AVI-4206 是一种选择性 Mac1 抑制剂，其抑制 Mac1 的催化活性的 IC50 为 64 nM。 AVI-4206 可降低 SARS-CoV-2 病毒复制、恢复干扰素应答，并在 SARS-CoV-2 感染的动物模型中显现出生存获益。AVI-4206 可用于 SARS-CoV-2 感染的相关研究。

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AVI-4206

AVI-4206 Chemical Structure

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AVI-4206 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AVI-4206 is a selective Mac1 inhibitor with an lC50 of 64 nM. AVI-4206 reduces viral replication, restores an interferon response, and leads to a survival benefit in an animal model of SARS-CoV-2 infection. AVI-4206 can be used the study of SARS-CoV-2 infection[1].

体外研究
(In Vitro)

AVI-4206 (0.1-1000000 nM) 在自体 ADP-核糖基化的 PARP10 和耦合 NudT5/AMP-Glo 测定中抑制 Mac1 的催化活性，其 IC50 为 64 nM[1]。
AVI-4206 (10 μM) 在 A549 细胞中与 Mac1 高效且选择性结合[1]。
AVI-4206 (0.01-10000 nM) 在 SARS-CoV-2 感染的 Vero-TMPRSS2 或 A549-ACE2h 细胞中疗效有限[1]。
AVI-4206 (0.16-100 μM, 24-72 h) 在 Mac1 缺失病毒 (WA1 N40D mutant) 感染后可减少病毒颗粒的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AVI-4206 相关抗体:
体内研究
(In Vivo)

AVI-4206 (100 mg/kg，腹腔注射，每日两次，连续 7 天) 在 K18-hACE2 小鼠 SARS-CoV-2 感染模型中具有疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female K18-hACE2 mice were infected with WA1 N40D mutant, which lacks Mac1 catalytic activity[1]
Dosage: 100 mg/kg
Administration: i.p., twice daily for 7 days (until 5 days post-infection)
Result: Showed weight loss at 4 days post-infection, but the extent of weight loss was about 5-10% lower on average at days 5-7 post-infection compared with respective vehicle-treated groups.
Reduced disease severity and prevent death in the K18-hACE2 model.
Showed the faster clearance of viral load in the lungs.
Increased the levels of antiviral cytokines IP-10, IL-2, IL-6, and TNF-α in lung tissue.
分子量

381.43

Formula

C19H23N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AVI-4206 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVI-4206AVI4206AVI 4206SARS-CoVSARS coronavirusSARS-CoV-2Mac1A549 cellsInhibitorinhibitorinhibit

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目录号：
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