2. Others Neuronal Signaling
  3. Drug Derivative Amyloid-β
  4. Aβ aggregation modulator-1

Aβ aggregation modulator-1 是一种 β-淀粉样蛋白 (Aβ) 纤维形成的促进剂。Aβ aggregation modulator-1 可结合 Aβ 肽中的疏水残基，并稳定富含 β-折叠的原纤维和纤维。Aβ aggregation modulator-1 能加速 Aβ 聚合，并在异质聚集反应中降低小型有毒 Aβ 寡聚体的浓度。Aβ aggregation modulator-1 能抑制 Aβ 寡聚体在海马脑切片中对长时程增强 (LTP) 的抑制作用。Aβ aggregation modulator-1 可用于阿尔茨海默病 (AD) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Aβ aggregation modulator-1

Aβ aggregation modulator-1 Chemical Structure

CAS No. : 71939-12-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Aβ aggregation modulator-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD)[1].

体外研究
(In Vitro)

Aβ42-IN-6 (Compound O4) (48 h) 可降低 Aβ42 诱导的分化 SH-SY5Y 细胞和原代皮层神经元的毒性[1]。
Aβ42-IN-6 (5-25 μM, 48 h) 可促进 SH-SY5Y 细胞培养基中 Aβ42 的聚集，降低可溶性 Aβ42 单体和小寡聚体的丰度，同时增加更大聚集体结构的形成[1]。
Aβ42-IN-6 (5 μM, 48 h) 可促进在 7PA2 细胞 (过表达突变人源 APP 的 CHO 细胞) 中形成 SDS 抗性的 Aβ 聚集体[1]。
Aβ42-IN-6 可抑制 Aβ42 在大鼠脑切片 CA1 区诱导的海马长时程增强 (LTP) 抑制作用，从而挽救由有毒 Aβ42 寡聚体引起的突触可塑性功能障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ aggregation modulator-1 相关抗体:
分子量

429.38

Formula

C24H15NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ aggregation modulator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ aggregation modulator-171939-12-3Aβ aggregation modulator1Aβ aggregation modulator 1Drug DerivativeAmyloid-βDrug derivativeβ-amyloid peptideAβAbetaAlzheimer's disease (AD)amyloid-βInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Aβ aggregation modulator-1
目录号：
HY-13325
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z