2. Neuronal Signaling
  3. Amyloid-β
  4. BChE-IN-8

BChE-IN-8 (compound 20) 是一种口服有效的、可透过血脑屏障的 BChE (丁酰胆碱酯酶)抑制剂，其 IC50 值分别为 0.15 nM (eqBChE) 和 45.2 nM (hBChE)。BChE-IN-8 的高稳定性有助于显著改善血液浓度和组织暴露。BChE-IN-8 可通过胆碱能系统、Aβ 聚集、神经肽水平等多种调控机制发挥神经保护和认知改善作用。BChE-IN-8 可用于阿尔茨海默病 (AD) 的研究。

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BChE-IN-8 Chemical Structure

BChE-IN-8 Chemical Structure

CAS No. : 2653349-78-9

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BChE-IN-8 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1].

IC50 & Target

IC50: 0.15 ± 0.10 nM (eqBChE), 45.2 ± 45.0 nM (hBChE) [1]
分子量

438.24

Formula

C18H12BrN7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-82653349-78-9Amyloid-ββ-amyloid peptideAβAbetaAlzheimer's diseaseADorally activeAβ aggregationneuro-protectingneuroprotectioncognitive improvementneurodegenerative diseasesInhibitorinhibitorinhibit

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