1. Apoptosis Metabolic Enzyme/Protease
  2. Ferroptosis Glutathione Peroxidase
  3. BCP-T.A

BCP-T.A,一种杂环亲电子试剂,通过与 GPX4 结合而有效地诱导铁死亡 (ferroptosis)。BCP-T.A 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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BCP-T.A Chemical Structure

BCP-T.A Chemical Structure

CAS No. : 2786829-70-5

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规格 价格 是否有货 数量
1 mg ¥670
3 - 4 周
5 mg   询价  
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1]. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

GPX4[1]

体外研究
(In Vitro)

BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM[1].
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

456.39

Formula

C23H19Cl2N3OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BCP-T.A
目录号:
HY-151212
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