2. Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel
  3. Apoptosis Calcium Channel
  4. Benidipine

Benidipine  (Synonyms: KW-3049 free base)

目录号: HY-B1448A
产品使用指南

摩尔计算器

Benidipine 是一种有效且具有口服活性的钙通道拮抗剂。Benidipine 对缺血/再灌注心肌细胞具有抗凋亡 (apoptosis) 作用。Benidipine 增加内皮细胞型一氧化氮合酶活性，改善高血压大鼠冠状动脉循环。

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Benidipine Chemical Structure

Benidipine Chemical Structure

CAS No. : 105979-17-7

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Benidipine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Benidipine is a potent and orally active calcium channel antagonist[1]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[2]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[3].

体内研究
(In Vivo)

Benidipine (3, 5, 10 µg/kg; i.v.) shows significant anti-apoptosis effects in a haemodynamically independent manner[2].
Benidipine (5 mg/kg; i.v.; every other day for 6 weeks) increases the activity of endothelial cell-type nitric oxide synthase (eNOS) and improves coronary circulation in hypertensive rats[3].
Benidipine (1, 3, 10 mg/kg; p.o.; once daily for 1 week) significant cardioprotective effects against ischemia-reperfusion injury[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sham MI (myocardial ischaemia)/R (ischmia reperfused injury) rabbits and MI/R rabbits[2]
Dosage: 3, 5, 10 µg/kg
Administration: I.v.
Result: Caused a significant decreased in HR ( heart rate), MABP (mean arterial blood pressure), PRI (pressure-rateindex) at 10 µg/kg, decreased apoptotic positive cells to7.4% at 3 µg/kg and not significantly different from that seen in the group treated with higher dose.
Animal Model: Renovascular hypertensive rats (RHR)[3]
Dosage: 5 mg/kg (dissolved in peanut oil)
Administration: I.v.; every other day for 6 weeks
Result: Significantly decreased the blood pressure and coronary vascular resistance index, but increased nitrite production and eNOS mRNA expression and significantly increased the coronary flow at rest, the capillary density.
Animal Model: Rats (heart model (Langendorff perfusion))[4]
Dosage: 1, 3, 10 mg/kg
Administration: P.o.; once daily for 1 week
Result: Significantly increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%; LV dP/dt max: 97.8±10.4 vs 70.2±15.7%; p<0.05) at 3 mg/kg.
Clinical Trial
分子量

505.56

Formula

C28H31N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Benidipine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Benidipine105979-17-7KW-3049KW3049KW 3049ApoptosisCalcium ChannelCa2+ channelsCa channelsanti-apoptosiseNOShypertensiveischaemic/reperfusedHRMABPPRIInhibitorinhibitorinhibit

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