1. Membrane Transporter/Ion Channel
  2. Na+/Ca2+ Exchanger Sodium Channel
  3. Benzamil

Benzamil  (Synonyms: Benzylamiloride)

目录号: HY-B1546
产品使用指南

Benzamil (Benzylamiloride),是 Amiloride 类似物,是一种 Na+/Ca2+ 交换体 (NCX) 抑制剂,(IC50~100 nM)。Benzamil 也是一种非选择性 Deg/epithelial sodium channels (ENaC) 阻滞剂,能增强肌源性血管收缩。Benzamil 抑制 TRPP3 介导的 Ca2+ 激活电流,IC50 为 1.1 μM。

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Benzamil Chemical Structure

Benzamil Chemical Structure

CAS No. : 2898-76-2

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Benzamil 的其他形式现货产品:

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  • 生物活性

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  • 参考文献

生物活性

Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].

体外研究
(In Vitro)

Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

319.75

Formula

C13H14ClN7O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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