Betulin  (Synonyms: Trochol)

Betulin (GMP) (Trochol (GMP)) is Betulin (HY-N0083) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line.

Betulin (GMP) 具有广泛的生物学和药理学特性，其中抗癌和化学预防活性引起了人们的广泛关注。Betulin (GMP) 已被证明可通过抑制癌细胞生长来引发抗癌特性。Betulin (GMP) 表现出相当不同的抗增殖活性，这取决于癌细胞类型，从对人红白血病细胞系 (K562) 的细胞增殖的微弱抑制到对人神经母细胞瘤细胞 (SK-N-AS) 的强烈抑制，其中效果最为显著。此外，还发现 Betulin (GMP) 对从卵巢癌、宫颈癌和胶质母细胞瘤患者的肿瘤样本中分离出的原代癌细胞培养物表现出显著的细胞毒性，IC₅₀ 值范围为 2.8 至 3.4 μM，与已建立的细胞系相比，显著降低。比较粗桦树皮提取物和纯化的桦木脑和桦木酸对人胃癌 (EPG85-257) 和人胰腺癌 (EPP85-181) 药物敏感和耐药 (柔红霉素和米托蒽醌) 细胞系的细胞毒活性^[1]。
根据所使用的化合物，细胞系之间的敏感性存在显著差异，这表明 Betulin 和桦木酸都可被视为处理癌症的有前途的先导物^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betulin (GMP) 可以改善葡萄糖耐受不良并改变基础学习表现。用 Betulin (GMP) 处理可显著恢复海马体中的 SOD 活性并降低 MDA 含量。Betulin (GMP) 还显著降低血清和海马中炎性细胞因子的含量。此外，Betulin (GMP) 的给药有效上调了 Nrf2、HO-1 的表达并阻断了 IκB、NF-κB 的磷酸化。综上所述，Betulin (GMP) 可能通过 HO-1/Nrf-2/NF-κB 通路对 STZ 诱导的糖尿病大鼠认知功能下降发挥保护作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

442.72

C₃₀H₅₀O₂

473-98-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Król SK, et al. Comprehensive review on betulin as a potent anticancer agent. Biomed Res Int. 2015;2015:584189.  [Content Brief]

  [2]. Drag M, et al. Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines. Molecules. 2009 Apr 24;14(4):1639-51.  [Content Brief]

  [3]. Ma C, et al. Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats. Neurotoxicology. 2016 Dec;57:104-111.  [Content Brief]