2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. BMS-341400 mesylate

BMS-341400 mesylate 是一种选择性的磷酸二酯酶 5 (PDE5) 抑制剂，IC50 值为 0.3 nM。BMS-341400 mesylate 减少环磷酸鸟苷 (cGMP) 的降解，从而增强一氧化氮 (NO) 介导的阴茎海绵体平滑肌松弛，促进勃起。BMS-341400 mesylate 可用于研究勃起功能障碍。

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BMS-341400 mesylate

BMS-341400 mesylate Chemical Structure

CAS No. : 296250-54-9

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BMS-341400 mesylate 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-341400 mesylate is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 mesylate reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 mesylate can be used to study erectile dysfunction[1][2].

IC50 & Target[1]

PDE5

0.3 nM (IC50)

体外研究
(In Vitro)

BMS-341400 (Compound 6) mesylate 能有效增强离体兔阴茎海绵体组织平滑肌的松弛，其 EC₅₀ 值为 13 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-341400 mesylate 相关抗体:
药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Dog 5.1 μmol/Kg p.o. F 42 %
Rat 2 μmol/Kg p.o. F 29 %
Dog 5.1 μmol/Kg p.o. T1/2 2 h
Rat 2 μmol/Kg p.o. T1/2 1.2 h
体内研究
(In Vivo)

BMS-341400 (Compound 6) (10-1000 nmol/kg，静脉注射，单次剂量) mesylate 能有效促进雄性兔模型的勃起反应，EC₅₀ 值为 100 nmol/kg[1]。
BMS-341400 (10-250 mg/kg) mesylate在大鼠中表现出良好的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthesia-induced male rabbit model[1]
Dosage: 10, 30, 100, 300, and 1000 nmol/kg
Administration: Intravenous injection (i.v.), single dose
Result: Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).
分子量

588.04

Formula

C24H26ClN9O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-341400 mesylate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

BMS-341400296250-54-9BMS341400BMS 341400Phosphodiesterase (PDE)RabbitRatsErectile dysfunctionanginaheadacheIntracavernosalBlood pressureInhibitorinhibitorinhibit

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