2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. BMS-505130 fumarate

BMS-505130 (fumarate) 是一种强效、选择性且具有口服活性的 5-羟色胺转运体抑制剂，其与 5-羟色胺转运体结合的 Ki 值为 0.18 nM (与去甲肾上腺素和多巴胺转运体结合的 Ki 值为 4.6 和 2.1 μM)。BMS-505130 (fumarate) 可用于神经系统疾病的研究，如抑郁症。

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BMS-505130 fumarate

BMS-505130 fumarate Chemical Structure

CAS No. : 859230-84-5

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BMS-505130 fumarate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-505130 (fumarate) is a potent, selective and orally active serotonin transport inhibitor with a Ki for binding to the serotonin transporter of 0.18 nM (Ki for norepinephrine and dopamine transporters of 4.6 and 2.1 μM, respectively). BMS-505130 (fumarate) can be used for the research of neurological disease, such as depression[1].

体内研究
(In Vivo)

BMS-505130 (fumarate) (5 mg/kg，口服) 可抑制大鼠的血清素摄取[1]。
BMS-505130 (fumarate) (1-30 mg/kg，腹腔注射或口服) 能显著缩短抑郁小鼠的不动时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Depressant mice[1]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Intraperitoneally injection or Orally administration
Result: Decreased immobility time in tail suspension test.
分子量

355.39

Formula

C19H21N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-505130 fumarate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-505130859230-84-5BMS505130BMS 5051305-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorSerotonin transporternorepinephrine and dopamine transporterneurologicaldepressionInhibitorinhibitorinhibit

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产品名称：
BMS-505130 fumarate
目录号：
HY-105297
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