1. PROTAC
  2. PROTAC Linkers
  3. Boc-Pip-alkyne-Ph-COOH

Boc-Pip-alkyne-Ph-COOH 是一种 PROTAC linker (PROTAC linker),属于 alkyl/ether 类。Boc-Pip-alkyne-Ph-COOH 可用于合成一系列 PROTAC 分子,如 ARD-266 (HY-133020)。ARD-266 有效诱导雄激素受体 (AR) 阳性 LNCaP,VCaP 和 22Rv1 前列腺癌细胞系中的 AR 蛋白降解,DC50 值为 0.2-1 nM。Boc-Pip-alkyne-Ph-COOH 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Boc-Pip-alkyne-Ph-COOH Chemical Structure

Boc-Pip-alkyne-Ph-COOH Chemical Structure

CAS No. : 2581824-70-4

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生物活性

Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1]. Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Alkyl/ether

 

分子量

329.39

Formula

C19H23NO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

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产品名称:
Boc-Pip-alkyne-Ph-COOH
目录号:
HY-133044
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