2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Bodipy TMR-X muscimol

Bodipy TMR-X muscimol 是一种 Bodipy 标记的 Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm)。Muscimol 是一种 GABAA 受体激动剂。Bodipy TMR-X muscimol 可用于对可逆的脑失活的扩散进行可视化。

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Bodipy TMR-X muscimol

Bodipy TMR-X muscimol Chemical Structure

CAS No. : 849464-08-0

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规格 价格 是否有货 数量
1 mg ￥4335
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Customer Review

Bodipy TMR-X muscimol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations[1].

IC50 & Target

GABAA receptor[1]
体内研究
(In Vivo)

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[2].
1. Rats are infused with Bodipy TMR-X muscimol as below: dilute the stock solution to 2 μg/μL (in PBS), infused into both hemispheres at a rate of 0.25 μL/min for a single minute, resulting in a final infusion volume of 0.25 μL and a final dose of 0.5 μg per side.
2. The animals are sacrificed by rapid decapitation 15 min after infusion in order to match the spread to what the experimental animals received immediately prior to behavioral testing.
3. The brains are removed and flash frozen in 45°C isopentane, stored at 80°C.
4. Coronal slices are sectioned at 60 μm. The slices are mounted on charged microscope slides and counterstained with DAPI.
5. The stained slices are incubated in a cool, dark room at room temperature for 3 d before being visualized with a confocal microscope.
6. A digital plate from the Paxinos and Watson (2007) rat brain atlas is overlaid on the image to visualize the spread.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

607.46

Formula

C31H36BF2N5O5
CAS 号
性状

固体

颜色

Brown to reddish brown

Emission (Em)

570
Excitation (Ex)

544
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (164.62 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6462 mL 8.2310 mL 16.4620 mL
5 mM 0.3292 mL 1.6462 mL 3.2924 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Bodipy TMR-X muscimol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6462 mL 8.2310 mL 16.4620 mL 41.1550 mL
5 mM 0.3292 mL 1.6462 mL 3.2924 mL 8.2310 mL
10 mM 0.1646 mL 0.8231 mL 1.6462 mL 4.1155 mL
15 mM 0.1097 mL 0.5487 mL 1.0975 mL 2.7437 mL
20 mM 0.0823 mL 0.4115 mL 0.8231 mL 2.0577 mL
25 mM 0.0658 mL 0.3292 mL 0.6585 mL 1.6462 mL
30 mM 0.0549 mL 0.2744 mL 0.5487 mL 1.3718 mL
40 mM 0.0412 mL 0.2058 mL 0.4115 mL 1.0289 mL
50 mM 0.0329 mL 0.1646 mL 0.3292 mL 0.8231 mL
60 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6859 mL
80 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5144 mL
100 mM 0.0165 mL 0.0823 mL 0.1646 mL 0.4115 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bodipy TMR-X muscimol849464-08-0GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBraininfusionlabeled muscimolInhibitorinhibitorinhibit

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