2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Muscimol

Muscimol  (Synonyms: 蝇蕈醇; Agarin; Agarine)

目录号: HY-N2313 纯度: ≥98.0%
COA 产品使用指南 技术支持

Muscimol (Agarin) 是一种精神活性异恶唑，是一种选择性神经递质 GABA 激动剂。Muscimol 在高亲和力和低亲和力位点结合 GABAA (Kd 分别为 10 和 270 nM)，刺激氯化物流出，EC50 值为 200 nM。Muscimol 可以透过血脑屏障 (BBB)，具有破坏记忆的作用。

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Muscimol

Muscimol Chemical Structure

CAS No. : 2763-96-4

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规格 价格 是否有货 数量
1 mg ￥1545
In-stock
5 mg ￥3400
In-stock
10 mg ￥6000
In-stock
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Other Forms of Muscimol:

Muscimol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Muscimol (Agarin), a psychoactive isoxazole, is a selective neurotransmitter GABA agonist. Muscimol Binds GABAA on both high- and low-affinity sites (Kd=10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Muscimol passes the blood-brain barrier (BBB) and has memory-disrupting effects[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
2.2 μM
Compound: 1
Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay
Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay
[PMID: 17655213]
IMR-32 EC50
2.04 μM
Compound: Muscimol
Agonist activity at GABA type-A receptor in human IMR32 cells after 2 hrs by Epic DMR assay
Agonist activity at GABA type-A receptor in human IMR32 cells after 2 hrs by Epic DMR assay
10.1039/C5MD00442J
Oocyte EC50
1.4 μM
Compound: Muscimol
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method
[PMID: 18528996]
分子量

114.10

Formula

C4H6N2O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

蝇蕈醇；毒蕈胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

Muscimol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscimol2763-96-4Agarin Agarine蝇蕈醇毒蕈胺GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorpsychoactive isoxazoleneurotransmitterchloride effluxblood-brain barrierbbbmemory-disrupting effectInhibitorinhibitorinhibit

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