2. GPCR/G Protein
  3. Endothelin Receptor
  4. BQ-3020

BQ-3020 是一种内皮素受体 (endothelin receptor) (ETBreceptor) 激动剂，取代[125I]ET-1 与猪小脑 ETB 受体结合，IC50 值为 0.2 nM。BQ-3020 引起兔肺动脉血管收缩和猪膀胱颈松弛，可用于心血管疾病研究。

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Custom Peptide Synthesis

BQ-3020 Chemical Structure

BQ-3020 Chemical Structure

CAS No. : 143113-45-5

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BQ-3020 的其他形式现货产品:

Customer Review

Other Forms of BQ-3020:

BQ-3020 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.

IC50 & Target

ETB

0.2 nM (IC50)

体外研究
(In Vitro)

BQ-3020（0.01–300 nM，7分钟）对 PhE 预收缩的尿路上皮剥离组织产生浓度依赖性松弛[1]。
BQ-3020 (0.01–200 nM，20 min) 通过抑制 ETB 受体引起兔肺动脉剂量依赖性血管收缩，其 EC50 值为 0.57 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BQ-3020 相关抗体:
体内研究
(In Vivo)

BQ-3020 (3 mg/kg 皮下注射, 单次给药) 可使癌痛小鼠模型在注射后 3 小时内的癌痛减轻约 50%[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cancer pain mouse model [3]
Dosage: 3 mg/kg
Administration: Injected subcutaneously at the site of the greatest tumor development
Result: Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection
分子量

2006.32

Formula

C96H140N20O25S
CAS 号
Sequence

Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening

Ac-Acetyl-LMDKEAVYFAHLDIIW
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BQ-3020 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BQ-3020143113-45-5BQ3020BQ 3020Endothelin ReceptorETB receptor agonistvasoconstrictioncardiovascular diseaseendothelin receptorcancer painInhibitorinhibitorinhibit

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目录号：
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