2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Brinzolamide hydrochloride

Brinzolamide hydrochloride  (Synonyms: AL-4862 hydrochloride)

目录号: HY-B0588A
产品使用指南

摩尔计算器

Brinzolamide (AL-4862) hydrochloride 是一种选择性的碳酸酐酶 II（carbonic anhydrase II）抑制剂，其 IC50 值为 3.2 nM。Brinzolamide hydrochloride 可以通过抑制睫状体 CA-II，降低房水分泌，从而降低眼压 (IOP)。可用于青光眼疾病的研究。

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Brinzolamide hydrochloride Chemical Structure

Brinzolamide hydrochloride Chemical Structure

CAS No. : 150937-43-2

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Brinzolamide hydrochloride 的其他形式现货产品:

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Other Forms of Brinzolamide hydrochloride:

Brinzolamide hydrochloride 相关抗体

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查看 Carbonic Anhydrase 亚型特异性产品:

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CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[1][2].

IC50 & Target[1]

hCA II

3.2 nM (IC50)

体内研究
(In Vivo)

Brinzolamide (7.5 mg or 12 mg) hydrochloride implanted in a silicone matrix is extremely well tolerated and provides sustained release of brinzolamide and significant reduction in intraocular pressure (IOP) for up to 28 days with no adverse effects or signs of toxicity in normotensive NZW rabbits[2].
The pharmacokinetic parameters of Brinzolamide hydrochloride in rabbits[1].

Intracameral Administration (4.5 mg) Intracameral Administration (4.5 mg) Topical Administration (500 mg) Topical Administration (500 mg)
PK Parameters Aqueous Humor Iris-Ciliary Body Aqueous Humor Iris-Ciliary Body
Tmax (h) 0.08 0.5 1 0.25
Cmax (ng/mL, ng/g) 11,050 1964 408 1245
Terminal t1/2 (h) 3.4 13 2 13.6
AUC0-24h (h*ng/mL, h*ng/g) 17,780 7725 1896 11414
AUC0-∞ (h*ng/mL, h*ng/g) 17,836 8839 1955 16628
Dose-normalized AUC0-∞ (h*/mL, h*/g) 4 2 0.004 0.03

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbits[2]
Dosage: 7.5 mg, 12 mg
Administration: Implant placed in the episcleral space
Result: Resulted in a significant IOP reduction of 4.6 mmHg on days 10-28, with concentrations of 12 mg.
Clinical Trial
分子量

419.97

Formula

C12H22ClN3O5S3
CAS 号
中文名称

布林佐胺盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Brinzolamide hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brinzolamide150937-43-2AL-4862布林佐胺盐酸盐AL4862AL 4862Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrase IIintraocular pressureIOPatrial fluidglaucomaInhibitorinhibitorinhibit

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