2. Anti-infection
  3. Bacterial
  4. Buforin II

Buforin II，来源于 buforin I，从亚洲蟾蜍 Bufo bufo gargarizans 胃中分离得到的蛋白，是一种高效的抗菌 (antimicrobial) 肽。Buforin II 对广谱的革兰氏阳性和革兰氏阴性细菌具有抗菌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Buforin II Chemical Structure

Buforin II Chemical Structure

CAS No. : 172998-24-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3800
In-stock
5 mg ￥8500
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Buforin II 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria[1].

体外研究
(In Vitro)

Buforin II inhibits A. baumanniiATCC 19606 and multiresistant strains with the similar MIC values of 8 mg/L[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Buforin II 相关抗体:
体内研究
(In Vivo)

Buforin II (intravenously a single dose, 1 mg/kg) has potent antibacterial activity that effectively reduces lethality and leads to a significant reduction in plasma endotoxin and cytokine concentrations in male Wistar rat model of sepsis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200 to 300 g with A. baumannii ATCC 19606[1]
Dosage: 1 mg/kg
Administration: Intravenously a single dose
Result: Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively.
Animal Model: Male Wistar rats weighing 200 to 300 g with the multiresistant strain[1]
Dosage: 1 mg/kg
Administration: Intravenously a single dose
Result: Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively.
分子量

2434.85

Formula

C106H184N40O26
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

TRSSRAGLQFPVGRVHRLLRK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (41.07 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4107 mL 2.0535 mL 4.1070 mL
5 mM 0.0821 mL 0.4107 mL 0.8214 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Buforin II 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4107 mL 2.0535 mL 4.1070 mL 10.2676 mL
5 mM 0.0821 mL 0.4107 mL 0.8214 mL 2.0535 mL
10 mM 0.0411 mL 0.2054 mL 0.4107 mL 1.0268 mL
15 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
20 mM 0.0205 mL 0.1027 mL 0.2054 mL 0.5134 mL
25 mM 0.0164 mL 0.0821 mL 0.1643 mL 0.4107 mL
30 mM 0.0137 mL 0.0685 mL 0.1369 mL 0.3423 mL
40 mM 0.0103 mL 0.0513 mL 0.1027 mL 0.2567 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Buforin II172998-24-2Bacterialbuforin IantimicrobialGram-positive bacteriaGram-negative bacteriaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Buforin II
目录号：
HY-P1630
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z