1. Protein Tyrosine Kinase/RTK Apoptosis
  2. c-Met/HGFR Apoptosis
  3. c-Met-IN-10

c-Met-IN-10 (compound 26a) 是一种高效的 c-Met 激酶抑制剂,IC50 为 16 nM。c-Met-IN-10 对癌细胞 A549、H460 和 HT-29 有抑制活性。c-Met-IN-10 抑制 HT-29 细胞集落形成,诱导 HT-29 和 A549 细胞凋亡 apoptosis,抑制 A549 细胞移动。c-Met-IN-10 可用于抗癌研究。

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c-Met-IN-10 Chemical Structure

c-Met-IN-10 Chemical Structure

CAS No. : 2415291-03-9

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  • 生物活性

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生物活性

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

分子量

516.48

Formula

C26H21FN6O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
c-Met-IN-10
目录号:
HY-146274
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