2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  3. DNA-PK Apoptosis
  4. Canfosfamide

Canfosfamide  (Synonyms: TLK-286; TER286)

目录号: HY-16124
产品使用指南

摩尔计算器

Canfosfamide (TLK-286) 是一种谷胱甘肽类似物前体药物，由谷胱甘肽 S-转移酶 P1-1 激活，诱导细胞凋亡 (apoptosis)。Canfosfamide还抑制 DNA 依赖性蛋白激酶 (DNA-PK) 的催化激酶活性。Canfosfamide 在活化后产生一种抗癌烷基化剂和谷胱甘肽衍生物。Canfosfamide 可用于恶性肿瘤的研究。

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Canfosfamide Chemical Structure

Canfosfamide Chemical Structure

CAS No. : 158382-37-7

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Canfosfamide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies[1][2][3].

IC50 & Target

IC50: ~1 µM (DNA-PK)[3]
体外研究
(In Vitro)

Canfosfamide (TLK-28) inhibit the catalytic kinase activity of purified DNA-dependent protein kinase (DNA-PK) with an IC50 value of ~1 µM, but causes minimal direct damage to DNA[2].
Canfosfamide (TER286) inhibits MCF-7, NIH-3T3 and M7609 in a dose-dependent manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Canfosfamide 相关抗体:

Cell Proliferation Assay[3]

Cell Line: MCF-7, NIH-3T3 and M7609
Concentration: 0-100 μM
Incubation Time: Co-incubated for 2 h then removed and incubated for 5 days in MCF-7; co-incubated for 10 days in NIH-3T3; co-incubated for 48 h in M7609
Result: Inhibited these cancer cell lines in a dose-dependent manner.
体内研究
(In Vivo)

Canfosfamide (TER286) exhibits more effective antitumor effect in more frequent administration[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (s.c. with tumors of M7609, MX-1 human breast tumor, lung tumor[3]
Dosage: 150 mg/kg for M7609 xenografts; 400 mg/kg or 200 mg/kg for other xenografts
Administration: i.v., single dosage for M7609 xenograft; i.p., single dosage for other xenografts; i.p., daily for 5 days
Result: The best response to TER286 was for the MX-1 human breast tumor treated with an aggressive regimen (daily for 5 days), under which nearly all of the tumors were either severely growth inhibited or substantially regressed.
Clinical Trial
分子量

787.47

Formula

C26H40Cl4N5O10PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Canfosfamide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canfosfamide158382-37-7TLK-286 TER286TLK286TLK 286TER286TER 286TER-286DNA-PKApoptosisDNA-dependent protein kinaseglutathionemalignanciesantitumoranticancerM7609MX-1MCF-7NIH-3T3Inhibitorinhibitorinhibit

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