2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Cantuzumab ravtansine

Cantuzumab ravtansine  (Synonyms: IMGN242; huC242-DM4)

目录号: HY-P99493 纯度: 98.71%
COA

摩尔计算器

Cantuzumab ravtansine (IMGN242; huC242-DM4) 是一种 ADC，由一种人源化单克隆抗体 huC242，通过二硫键与 DM4 (DM4; HY-12454) 共价连接。Cantuzumab ravtansine 对一系列 CanAg 阳性人肿瘤异种移植物具有广泛的抗肿瘤功效。

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Cantuzumab ravtansine Chemical Structure

Cantuzumab ravtansine Chemical Structure

CAS No. : 868747-45-9

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1 mg ￥7800
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Cantuzumab ravtansine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (DM4 (HY-12454)). Cantuzumab ravtansine has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].

体外研究
(In Vitro)

Cantuzumab ravtansine（huC242-DM4；5 天）在 CanAg 阳性 SNU16 胃癌细胞中表现出细胞毒性作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cantuzumab ravtansine 相关抗体:
体内研究
(In Vivo)

Cantuzumab ravtansine（huC242-DM4；静脉注射；3.4 mg/kg；单剂量）可使携带 N87 人胃肿瘤异种移植物的 SCID 小鼠的肿瘤完全消退，在低于 2 mg/kg 的剂量下观察到显着的肿瘤消退 [1]。
Cantuzumab ravtansine (huC242-DM4) 在携带人结肠肿瘤异种移植物 HT29 和 COLO 205 细胞的小鼠中也有疗效，且无毒副作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cantuzumab ravtansine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantuzumab ravtansine868747-45-9IMGN242 huC242-DM4IMGN 242IMGN-242Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug Conjugatesdisulfide linkageADChuC242CanAg-positiveInhibitorinhibitorinhibit

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