2. Anti-infection
  3. Bacterial Antibiotic
  4. Capreomycin

Capreomycin 是一种大环肽类抗生素 (antibiotic)。Capreomycin 可用于抗多耐药性结核分枝杆菌的研究。Capreomycin 可抑制分枝杆菌核糖体转译中苯丙氨酸的合成。

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Custom Peptide Synthesis

Capreomycin Chemical Structure

Capreomycin Chemical Structure

CAS No. : 11003-38-6

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Capreomycin 的其他形式现货产品:

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Capreomycin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation[1][2]

IC50 & Target

Aminoglycoside

 

体内研究
(In Vivo)

Capreomycin (1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.; 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 105 CFU/mL of Mycobacterium tuberculosis (strain H37Rv)][2]
Dosage: 1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.
Administration: Inhaling or i.m.; 4 weeks
Result: Significantly decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls.
Significantly lowered bacterial burden in the lungs (3.52 ± 0.20 CFU/mL; P < 0.05) at 14.5 mg/kg than controls (4.58 ± 0.20 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 ± 0.32 and 4.01 ± 0.29 CFU/mL, respectively).
Clinical Trial
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Capreomycin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Capreomycin11003-38-6BacterialAntibioticTuberculosisMycobacterialMycobacterium tuberculosisantibacterialInhibitorinhibitorinhibit

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