2. Peptides
  3. CAQK peptide

CAQK peptide 选择性地结合受损的小鼠脑部。CAQK peptide 选择性地靶向脱髓鞘区域，并且健康组织中不存在该肽。CAQK peptide 靶标是脑损伤时上调的蛋白聚糖复合物，可用于药物递送。CAQK peptide 可以透过血脑屏障。

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Custom Peptide Synthesis

CAQK peptide Chemical Structure

CAQK peptide Chemical Structure

CAS No. : 2088281-24-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

CAQK peptide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier[1][2].

体外研究
(In Vitro)

FAM-CAQK 选择性地与局灶性和撞击引起的脑损伤相关，而不与健康的大脑和其他组织相互作用。在病变部位，肽主要与沉积在反应性星形胶质细胞附近的间质空间中的纤维细胞外基质 (ECM) 相关[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAQK peptide 相关抗体:
体内研究
(In Vivo)

CAQK (100 nmoles/100 µL；尾静脉；损伤后 24 小时或 5 天) 定位于急性溶血卵磷脂注射液引起的局灶性脱髓鞘位点。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J 8-week-old male mice[1]
Dosage: 100 nmoles/100 μl in PBS
Administration: Tail vein; at 24 h or 5 days post-injury (focal demyelination was induced by stereotaxic injection of 1 μL of 1% lysolecithin solution into the right ventral)
Result: Caused the accumulation of peptide at the injury site by an increased density of mononucleated DAPI+ cells and fragmented myelin stained for myelin basic protein.
The peptide was not detected in the spinal cords of control sham-operated (PBS injected) mice showing regular densities of DAPI+ cells.
分子量

448.54

Formula

C17H32N6O6S
CAS 号
Sequence

Cys-Ala-Glu-Lys
Sequence Shortening

CAQK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAQK peptide2088281-24-5Othersdrug deliverydemyelinating areasproteoglycan complexblood-brain barrierInhibitorinhibitorinhibit

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产品名称：
CAQK peptide
目录号：
HY-P10216
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