2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. Carboxypyridostatin

Carboxypyridostatin 是一种 G-四联体 (G-quadruplex) 配体。Carboxypyridostatin 对 DNA G4s 上的 RNA 具有高度分子特异性，并可降低 ATF-5 蛋白。Carboxypyridostatin 可抑制细胞增殖并阻碍应激颗粒 (SG) 的形成。

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Carboxypyridostatin

Carboxypyridostatin Chemical Structure

CAS No. : 1417638-60-8

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Carboxypyridostatin 的其他形式现货产品:

Other Forms of Carboxypyridostatin:

Carboxypyridostatin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation[1][2][3].

体外研究
(In Vitro)

Carboxypyridostatin (1-25 μM；3 天) 可减小成年 SVZ 衍生神经球的大小和神经球中的细胞数量，并阻止成年 SVZ 衍生神经球培养物增殖和神经球融合[1]。
Carboxypyridostatin (10 μM；24 h) 可阻碍 U2OS 细胞中的应激颗粒 (SG) 形成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carboxypyridostatin 相关抗体:
体内研究
(In Vivo)

Carboxypyridostatin (10 mg/kg；腹腔注射；每 12 h 一次；注射 3 次) 显著减少成年小鼠 SVZ 中表达 PCNA 的细胞数量，并增加小鼠胼胝体中表达 OLIG2 的细胞数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (both sexes, 1-2 months old)[1]
Dosage: 10 mg/kg (dissolved in phosphate-buffered saline)
Administration: Intraperitoneal injection, every 12 h, 3 injections
Result: Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation.
Increased the number of OLIG2-expressing cells in the corpus callosum.
Showed no increase in OLIG2-expression in the SVZ.
Affected the differentiation of neural stem and progenitor cells in different brain regions.
分子量

706.71

Formula

C35H34N10O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carboxypyridostatin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carboxypyridostatin1417638-60-8G-quadruplexDNA G4sRNAmiceadult neural stem cellsprogenitor cellsU2OSInhibitorinhibitorinhibit

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