Carumonam  (Synonyms: AMA-1080; Ro 17-2301)

Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis^[1].

Carumonam 对肠杆菌科分离株的 MIC₉₀ 为 0.013-25 μg/mL，对铜绿假单胞菌的 MIC₉₀ 为 12.5 μg/mL^[1]。
Carumonam (0-400 μg/mL) 对肠杆菌科和铜绿假单胞菌的 PBP-3 有高亲和力，IC₅₀ 与对应的 MIC 值相同或更小^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carumonam (20 mg/kg; 皮下注射或肌肉注射; 单剂量) 在小鼠、大鼠、兔子、狗和食蟹猴体内的药代动力学特征显示，它容易被吸收，在血浆、肾脏、肝脏和肺部的分布浓度高^[2]。
动物: 5 周龄雄性 Slc:ICR 小鼠 (20-25 g)， 7 周龄雄性 Jcl:SD 大鼠 (210-250 g)，雄性新西兰大白兔 (2.5-3.5 kg)，雌雄比格犬 (10-15 kg)，雌性食蟹猴 (2.8-3.7 kg)。在使用抗生素之前，它们被剥夺饲料 16 至 18 小时；水被随意给予^[2]。

药代动力学分析^[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

466.40

C₁₂H₁₄N₆O₁₀S₂

87638-04-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7.  [Content Brief]

  [2]. Kita Y, et al. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother. 1986 Jan;29(1):127-34.  [Content Brief]