2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin K inhibitor 3

Cathepsin K inhibitor 3 (compound 23) 是一种高选择性的 cathepsin K 抑制剂，其 IC50 值为 0.5 nM。Cathepsin K inhibitor 3 具有良好的药代动力学特征，可用于骨关节炎 (OA) 疾病的研究。

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Cathepsin K inhibitor 3 Chemical Structure

Cathepsin K inhibitor 3 Chemical Structure

CAS No. : 1694638-70-4

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Cathepsin K inhibitor 3 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].

IC50 & Target[1]

cathepsin K

0.5 nM (IC50)

体内研究
(In Vivo)

Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1].
The pharmacokinetic parameters of compound 23

Parameters Cl(mL/min/kg) T1/2(h) %F
Rat 13 1 33
Dog 3.1 4.1 38
Rhesus 18.5 2.3 55

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

562.65

Formula

C30H31FN4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cathepsin K inhibitor 3 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Cathepsin K inhibitor 31694638-70-4Cathepsin K inhibitor3Cathepsin K inhibitor-3CathepsinCathepsin KosteoarthritisInhibitorinhibitorinhibit

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