1. GPCR/G Protein
  2. G Protein-coupled Receptor Kinase (GRK)
  3. CCG-271423

CCG-271423 是一种有效的选择性 GRK5 抑制剂,GRK5 和 GRK2 的 IC50 值分别为 0.0021 μM 和 44 μM。CCG-271423 抑制心肌细胞收缩能力,降低 Ca2+瞬态。CCG-271423 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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CCG-271423 Chemical Structure

CCG-271423 Chemical Structure

CAS No. : 2750413-88-6

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience[1]. CCG-271423 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 0.0021 μM (GRK5) and 44 μM (GRK5)[1]

体外研究
(In Vitro)

CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca2+ transience[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

466.53

Formula

C28H26N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CCG-271423
目录号:
HY-150039
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