Cefetamet hydrochloride  (Synonyms: Ro 15-8074 hydrochloride; Deacetoxycefotaxime hydrochloride)

Cefetamet (Ro 15-8074) hydrochloride is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet hydrochloride binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet hydrochloride has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet hydrochloride kills and lyses Treponema pallidum. Cefetamet hydrochloride can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis^{[1][2][3][4][5]}.

IC₅₀: 2.5 μg/mL (PBP3 in Escherichia coli W3110^[3]

Cefetamet hydrochloride 对大多数肠杆菌科细菌、流感嗜血杆菌、奈瑟菌属和肺炎链球菌 (MIC₉₀ ≤ 2 μg/mL) 均表现出较高的体外活性^[2]。
Cefetamet hydrochloride 对肠杆菌科细菌、奈瑟菌属、弧菌属、流感嗜血杆菌和链球菌 (除肠球菌) 均表现出较高的体外活性^[3]。
Cefetamet hydrochloride 对金黄色葡萄球菌的 PBP 表现出较差的亲和力，对 PBP 1 至 4 的 IC₅₀ 分别为 90、>100、52 和 >100 μg/mL^[3]。
Cefetamet (0.05-0.1 μg/mL; 24 h) hydrochloride 可在体外杀死和裂解梅毒螺旋体^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefetamet (1-30 mg/kg；肌肉注射；一次) hydrochloride 可治愈兔子实验性梅毒，在临床表现出现之前服用效果最佳^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

433.89

C₁₄H₁₆ClN₅O₅S₂

724438-16-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang W, et al. Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog. Eur J Drug Metab Pharmacokinet. 2015 Dec;40(4):401-7.  [Content Brief]

  [2]. Wise R, et al. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother. 1986 Jun;29(6):1067-72.  [Content Brief]

  [3]. Angehrn P, et al. In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil. Eur J Clin Microbiol Infect Dis. 1989 Jun;8(6):536-43.  [Content Brief]

  [4]. Fitzgerald TJ. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis. Antimicrob Agents Chemother. 1992 Mar;36(3):598-602.  [Content Brief]

  [5]. Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993;45(4):589-621.  [Content Brief]