1. Anti-infection Metabolic Enzyme/Protease
  2. Antibiotic Bacterial Penicillin-binding protein (PBP) Drug Metabolite
  3. Cefetamet hydrochloride

Cefetamet hydrochloride  (Synonyms: Ro 15-8074 hydrochloride; Deacetoxycefotaxime hydrochloride)

目录号: HY-A0111B
产品使用指南 技术支持

Cefetamet (Ro 15-8074) hydrochloride 是一种头孢类抗生素 (antibiotic) 和 Cefetamet pivoxil (HY-B1894A) 的活性代谢产物。Cefetamet hydrochloride 与细菌青霉素结合蛋白 (PBP) 结合 (对 Escherichia coli W3110 中 PBP3 的 IC50 为 2.5 μg/mL)。Cefetamet hydrochloride 对肠杆菌科、奈瑟菌属、流感嗜血杆菌等革兰氏阴性菌及链球菌等革兰氏阳性菌有显著活性。Cefetamet 杀死和裂解梅毒螺旋体。Cefetamet hydrochloride 可用于呼吸道、泌尿道、耳鼻喉等感染及梅毒的研究。

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Cefetamet hydrochloride

Cefetamet hydrochloride Chemical Structure

CAS No. : 724438-16-8

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Cefetamet hydrochloride 的其他形式现货产品:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cefetamet (Ro 15-8074) hydrochloride is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet hydrochloride binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet hydrochloride has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet hydrochloride kills and lyses Treponema pallidum. Cefetamet hydrochloride can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis[1][2][3][4][5].

IC50 & Target

IC50: 2.5 μg/mL (PBP3 in Escherichia coli W3110[3]

体外研究
(In Vitro)

Cefetamet hydrochloride 对大多数肠杆菌科细菌、流感嗜血杆菌、奈瑟菌属和肺炎链球菌 (MIC90 ≤ 2 μg/mL) 均表现出较高的体外活性[2]
Cefetamet hydrochloride 对肠杆菌科细菌、奈瑟菌属、弧菌属、流感嗜血杆菌和链球菌 (除肠球菌) 均表现出较高的体外活性[3]
Cefetamet hydrochloride 对金黄色葡萄球菌的 PBP 表现出较差的亲和力,对 PBP 1 至 4 的 IC50 分别为 90、>100、52 和 >100 μg/mL[3]
Cefetamet (0.05-0.1 μg/mL; 24 h) hydrochloride 可在体外杀死和裂解梅毒螺旋体[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cefetamet (1-30 mg/kg;肌肉注射;一次) hydrochloride 可治愈兔子实验性梅毒,在临床表现出现之前服用效果最佳[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

433.89

Formula

C14H16ClN5O5S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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