1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. STING
    Endogenous Metabolite
  3. cGAMP diammonium

cGAMP diammonium (Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium)

目录号: HY-110385A
产品使用指南

cGAMP (Cyclic GMP-AMPP) diammonium 作为内源性第二信使发挥作用,并触发干扰素的产生以响应胞浆 DNA。cGAMP diammonium 激活干扰素基因刺激因子 (STING),激活导致产生 I 型干扰素和其他免疫介质的信号级联。

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cGAMP diammonium Chemical Structure

cGAMP diammonium Chemical Structure

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规格 价格 是否有货 数量
500 μg ¥1900 In-stock
1 mg ¥3300 In-stock
5 mg ¥12000 In-stock
10 mg   询价  
50 mg   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP diammonium directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

cGAMP (5 µg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
分子量

708.47

Formula

C₂₀H₃₀N₁₂O₁₃P₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
cGAMP diammonium
目录号:
HY-110385A
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