1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. STING
    Endogenous Metabolite
  3. cGAMP diammonium

cGAMP diammonium (Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium)

目录号: HY-110385A

cGAMP (Cyclic GMP-AMPP) diammonium 作为内源性第二信使发挥作用,并触发干扰素的产生以响应胞浆 DNA。cGAMP diammonium 激活干扰素基因刺激因子 (STING),激活导致产生 I 型干扰素和其他免疫介质的信号级联。

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cGAMP diammonium Chemical Structure

cGAMP diammonium Chemical Structure

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500 μg ¥1900 In-stock
1 mg ¥3300 In-stock
5 mg ¥12000 In-stock
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cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite


(In Vitro)

cGAMP diammonium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP diammonium directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP diammonium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP diammonium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

cGAMP (5 µg; nostril mucosal adjuvant) diammonium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.





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cGAMP diammonium