2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Chloropurine riboside

Chloropurine riboside  (Synonyms: 6-Chloropurine riboside)

目录号: HY-W007791 纯度: 99.93%
COA 产品使用指南 技术支持

Chloropurine riboside (6-Chloropurine riboside) 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向治疗惰性淋巴系统恶性肿瘤。嘌呤核苷类似物是已证实对血液系统恶性肿瘤具有活性的细胞毒药物。该过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等。

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Chloropurine riboside

Chloropurine riboside Chemical Structure

CAS No. : 5399-87-1

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Chloropurine riboside 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chloropurine riboside (6-Chloropurine riboside) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Purine nucleoside analogs represent cytotoxic agents with established activity in hematological malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 CC50
> 200 μM
Compound: 7
Cytotoxicity against Huh7 cells by XTT assay
Cytotoxicity against Huh7 cells by XTT assay
[PMID: 17766124]
Huh-7 EC50
31 μM
Compound: 7
Inhibition of HCV replication in Huh7 cells after 48 hrs by luciferase assay
Inhibition of HCV replication in Huh7 cells after 48 hrs by luciferase assay
[PMID: 17766124]
Vero IC50
48.7 μM
Compound: 1
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
[PMID: 17336519]
分子量

286.68

Formula

C10H11ClN4O4
CAS 号
性状

固体

颜色

Off-white to yellow

中文名称

6-氯-9-(β-D-呋喃核糖苷)嘌呤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.93%

COA (294 KB) HNMR (122 KB) RP-HPLC (250 KB)

产品使用指南 (1538 KB)
参考文献

Chloropurine riboside 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloropurine riboside5399-87-16-Chloropurine riboside6-氯-9-(β-D-呋喃核糖苷)嘌呤Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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