1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Cimaterol

Cimaterol  (Synonyms: 西马特罗; CL 263780)

目录号: HY-100935
产品使用指南

Cimaterol (CL 263780) 是一种 β-肾上腺素能 (β-adrenergic) 激动剂。Cimaterol 与 L6 β-受体结合的 Kd 为 26 nM,与其用于刺激蛋白质合成的 EC50 (约 5 nM) 相容。

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Cimaterol Chemical Structure

Cimaterol Chemical Structure

CAS No. : 54239-37-1

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  • 参考文献

生物活性

Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].

IC50 & Target[1]

β-adrenoceptor

 

体外研究
(In Vitro)

Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 µM) shows a significant increase of cAMP concentration subsequent drug exposure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Mouse C2C12 myoblast cells
Concentration: 0.1 and 1 µM
Incubation Time: 8 days
Result: Fast proliferation with an increase of absorbance was noticed in treated cells compared to untreated cells at days 1, 2, and 3. From day 5 to day 8, the trend was reversed with absorbance in control cells significantly greater than that of treated cells.
体内研究
(In Vivo)

Cimaterol stimulates skeletal muscle gain in ob/ob mice[1].
Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: One hundred fifty crossbred pigs (55 kg)[4]
Dosage: Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
Administration:
Result: Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.
Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
分子量

219.28

Formula

C12H17N3O

CAS 号
中文名称

西马特罗;喜马特罗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-100935
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