2. GPCR/G Protein
  3. Amylin Receptor
  4. Cyclic AC253

Cyclic AC253 是 amylin 受体 的拮抗剂，IC50 为 0.3 μM。Cyclic AC253 对 Aβ 毒性具有神经保护功效，并消除 Aβ 诱导的海马长时程增强损伤。Cyclic AC253 具有血脑屏障通透性。

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Custom Peptide Synthesis

Cyclic AC253 Chemical Structure

Cyclic AC253 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Cyclic AC253 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB)[1].

体外研究
(In Vitro)

Cyclic AC253 (0-10 μM) 可保护神经元细胞 HFN 和 N2a 免受 Aβ1-42 诱导的细胞毒性和细胞凋亡 (apoptosis)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic AC253 相关抗体:
体内研究
(In Vivo)

Cyclic AC253 (200 μg/kg，腹腔注射，每周 3 次，持续 10 周) 可提高 TgCRND8 小鼠模型的认知缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alzheimer’s Disease in TgCRND8 mice model[1]
Dosage: 200 μg/kg
Administration: ip, 3 times a week for 10 weeks
Result: Improved cognitive deficits.
分子量

3009.34

Formula

C126H202N42O40S2
Unlabeled Cas

Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2 (Disulfide bridge: Cys1-Cys26)
Sequence Shortening

CLGRLSQELHRLQTYPRTNTGSNTYC-NH2 (Disulfide bridge: Cys1-Cys26)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cyclic AC253 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic AC253Cyclic AC 253Cyclic AC-253Amylin ReceptorAMYRAlzheimer's DiseaseTgCRND8 miceBBB penetrateHEK29Inhibitorinhibitorinhibit

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目录号：
HY-P10235
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