2. Protein Tyrosine Kinase/RTK
  3. Discoidin Domain Receptor
  4. DDR1-IN-12

DDR1-IN-12 (Compound 7t) 是一种高选择性的盘状结构域受体 1 (DDR1) 抑制剂 (IC50=0.126 μM)。DDR1-IN-12 能够阻断受体酪氨酸激酶的自身磷酸化以及下游信号传导 (例如抑制 TGF-β1 诱导的成纤维细胞活化)，从而抑制肿瘤细胞迁移和肺纤维化进展。DDR1-IN-12 有望用于肺癌 (尤其是肺腺癌) 的研究。

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DDR1-IN-12

DDR1-IN-12 Chemical Structure

CAS No. : 3038810-93-1

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DDR1-IN-12 相关抗体

Top Publications Citing Use of Products

查看 Discoidin Domain Receptor 亚型特异性产品:

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DDR1 DDR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDR1-IN-12 (Compound 7t) is a highly selective discoidin domain receptor 1 (DDR1) inhibitor (IC50=0.126 μM). DDR1-IN-12 blocks receptor tyrosine kinase autophosphorylation and downstream signaling (e.g., inhibition of TGF-β1-induced fibroblast activation), inhibiting tumor cell migration and pulmonary fibrosis progression. DDR1-IN-12 is promising for research of lung cancer (especially lung adenocarcinoma)[1].

IC50 & Target

DDR1

0.126 μM (IC50)

分子量

491.48

Formula

C24H25F4N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDR1-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDR1-IN-123038810-93-1Discoidin Domain ReceptorDDR1tumor cell migrationpulmonary fibrosis progressionInhibitorinhibitorinhibit

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