2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Dehydro Palonosetron

Dehydro Palonosetron  (Synonyms: RS 42358-197)

目录号: HY-44132
产品使用指南

摩尔计算器

Dehydro Palonosetron (RS 42358-197) 是一种有效的、选择性的、具有口服活性的 5-HT3 受体拮抗剂。Dehydro Palonosetron 对 5-HT1 受体、5-HT2 受体或 5-HT4 受体的活性没有影响。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Dehydro Palonosetron Chemical Structure

Dehydro Palonosetron Chemical Structure

CAS No. : 135729-56-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Dehydro Palonosetron:

Dehydro Palonosetron 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors[1].

IC50 & Target[1]

5-HT3 Receptor

 

体外研究
(In Vitro)

在体外功能实验中，Dehydro Palonosetron (RS 42358-197) 作为竞争性拮抗剂，对抗 5-HT 诱导的豚鼠回肠收缩，产生的 pA2 估计值为 8.1。Dehydro Palonosetron 对 5-HT1 样受体、5-HT2 受体或 5-HT4 受体没有任何激动或拮抗活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydro Palonosetron 相关抗体:
体内研究
(In Vivo)

在麻醉大鼠中，Dehydro Palonosetron (RS 42358-197) 通过静脉内、十二指肠内或经皮途径给药，剂量依赖性地抑制 2-甲基 5-HT 诱导的 Bezold-Jarisch 反射 (ID50：0.05 μg/kg；i.v.，5.7 μg/kg；i.d.，和 11.6 μg/室)[1]。
Dehydro Palonosetron (RS 42358-197；0.01 ng/kg-10 mg/kg；口服；一次) 可抑制因明/暗测试盒的厌恶情况而抑制的小鼠行为[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino BKW mice (30-35 g)[2]
Dosage: 0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result: Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.
分子量

294.39

Formula

C19H22N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dehydro Palonosetron 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydro Palonosetron135729-56-5RS 42358-1975-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT3 receptororally activeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Dehydro Palonosetron
目录号：
HY-44132
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z