Dehydromiltirone  (Synonyms: 1,2-Didehydromiltirone)

Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research^[1][2].

Dehydromiltirone (100 μg/mL; 24 h) 抑制 Kupffer 细胞中的 p38 和 NF-κB 信号^[1]。
Dehydromiltirone 抑制破骨细胞相关基因的表达，包括 NFATc1、CTSK、c-Fos、Acp5 和 MMP9；以及MAPK信号通路的 P38、ERK 和 JNK 的磷酸化；以及 NF-κB 信号通路中 IκB-α 的降解。Dehydromiltirone 通过降低相关基因的表达来发挥抗破骨细胞生成作用，最终在体外抑制骨吸收^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydromiltirone (50-200 mg/kg，口服；每天；连续五天) 保护肝脏免受 CCl4 诱导的损伤。Dehydromiltirone 可减少促炎细胞因子 TNF-α、IL-1 和 IL-6 的增加，表明它具有减轻肝脏炎症的作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

280.36

C₁₉H₂₀O₂

116064-77-8

去氢丹参新酮

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85.  [Content Brief]

  [2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693.  [Content Brief]