2. Anti-infection
  3. Antibiotic Bacterial
  4. Demeclocycline calcium

Demeclocycline calcium 是一种具有口服活性的四环素类抗生素，通过与 30S 核糖体亚单位结合来抑制氨基酰 tRNA 的结合，从而影响蛋白质的合成。Demeclocycline calcium 对广谱的细菌感染表现出抗菌活性。

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Demeclocycline calcium

Demeclocycline calcium Chemical Structure

CAS No. : 17146-81-5

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Demeclocycline calcium 的其他形式现货产品:

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Demeclocycline calcium 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Demeclocycline calcium is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline calcium exhibits antibacterial activity against a broad spectrum of bacterial infections[1][2].

体外研究
(In Vitro)

Demeclocycline (0-100 μM; 24 小时) calcium 处理可降低 mpkCCD 细胞中的 AQP2 丰度[3].
Demeclocycline (10 μM; 24 小时) calcium 处理可促进单核细胞的活性，并巨噬细胞[4]。
Demeclocycline (1-10 μM；72 小时) calcium 治疗直接影响脑肿瘤起始细胞的生长[4]。 Mouse bone marrow derived macrophages and monocytes 10 μM 24 hours Enhanced TNF-α production and modulated monocyte functions. Brain tumorinitiating cells 1, 5, and 10 μM 72 hours Inhibited cells growth in two ways: using monocytes as an intermediary, and directly by affecting the proliferation and sphere-forming capacity of brain tumorinitiating cells.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Demeclocycline calcium 相关抗体:

Western Blot Analysis[3]

Cell Line: MpkCCD cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: Decreased AQP2 abundance in mpkCCD cells, with significant effects at 50 μM.

Cell Viability Assay[4]

Cell Line: Mouse bone marrow derived macrophages and monocytes
Concentration: 10 μM
Incubation Time: 24 hours
Result: Enhanced TNF-α production and modulated monocyte functions.

Cell Viability Assay[4]

Cell Line: Brain tumorinitiating cells
Concentration: 1, 5, and 10 μM
Incubation Time: 72 hours
Result: Inhibited cells growth in two ways: using monocytes as an intermediary, and directly by affecting the proliferation and sphere-forming capacity of brain tumorinitiating cells.
体内研究
(In Vivo)

Demeclocycline (腹膜内注射；40 mg/kg；每日一次；48 小时) calcium 治疗可显著降低低钠血症并显著纠正低渗透压，且无肾毒性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats induced with hyponatremia[3]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
Result: Increased urine volume, decreased urine osmolality, and caused a significantly increased fractional excretion of water.
Indicated the effect in the renal inner medulla for AQP2 and AC5/6 specifically, and not secondary toxicity effect.
Clinical Trial
分子量

484.89

Formula

C21H21ClN2O8.1/2Ca1
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Demeclocycline calcium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Demeclocycline17146-81-5AntibioticBacterialanti-bacterial activityMpkCCDmacrophagesmonocytesbrain tumorinitiating cellsInhibitorinhibitorinhibit

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