1. PROTAC
  2. Target Protein Ligand-Linker Conjugate
  3. Desmorpholinyl Quizartinib-PEG2-COOH

Desmorpholinyl Quizartinib-PEG2-COOH 

目录号: HY-131230 纯度: 95.09%
产品使用指南

Desmorpholinyl Quizartinib-PEG2-COOH 包含靶蛋白 FLT-3 配体和一种基于 PEG 的 PROTAC Linker。Desmorpholinyl Quizartinib-PEG2-COOH 可用于合成 PROTAC FLT-3 degrader 1 (HY-114323)。PROTAC FLT-3 degrader 1 是 PROTAC FLT-3 ITD 降解剂,IC50 为 0.6 nM。

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Desmorpholinyl Quizartinib-PEG2-COOH Chemical Structure

Desmorpholinyl Quizartinib-PEG2-COOH Chemical Structure

CAS No. : 2292116-14-2

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Description

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].

Molecular Weight

607.68

Formula

C₃₀H₃₃N₅O₇S

CAS No.

2292116-14-2

SMILES

O=C(O)CCOCCOCCOC1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Desmorpholinyl Quizartinib-PEG2-COOHTarget Protein Ligand-Linker ConjugateInhibitorinhibitorinhibit

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产品名称:
Desmorpholinyl Quizartinib-PEG2-COOH
目录号:
HY-131230
需求量: