DETQ 

DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC₅₀ of 5.8 nM and a K_b of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor^[1].

DETQ (10 mg/kg；腹腔注射；一次) 改善雄性人源化 D1 受体敲入小鼠的亚慢性 Phencyclidine 诱导的物体识别记忆缺陷并增强皮质乙酰胆碱流出^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

422.34

C₂₂H₂₅Cl₂NO₃

1638667-81-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kjell A Svensson, et al. An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128.  [Content Brief]

  [2]. Herbert Y Meltzer, et al. The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice. Behav Brain Res. 2019 Apr 1;361:139-150.  [Content Brief]