2. Metabolic Enzyme/Protease
  3. MAGL
  4. DH-376

DH-376 是一种有效的甘油二酯脂肪酶抑制剂，对 ABHD6 和 DAGLα 的 pIC50 值分别为 8.6 和 8.9。DH-376 可防止禁食诱导的小鼠重新进食。DH-376 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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DH-376 Chemical Structure

DH-376 Chemical Structure

CAS No. : 1848233-57-7

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DH-376 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice[1]. DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体内研究
(In Vivo)

DH-376 (50 mg/kg; i.p.) 减少小鼠禁食诱导的再喂食[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male C57Bl/6J mice[1]
Dosage: 50 mg/kg
Administration: intraperitoneal injection
Result: Inhibitd fasting-induced refeeding.
分子量

542.58

Formula

C31H28F2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DH-376 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DH-3761848233-57-7DH376DH 376MAGLMonoacylglycerol lipaseInhibitorinhibitorinhibit

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