2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DHPS-IN-2

DHPS-IN-2 是一种变构脱氧羟嘌呤合酶 (DHPS) 抑制剂，其 IC50 为 70 nM，Kd 为 26.4 μM。DHPS-IN-2 在体外显著抑制黑色素瘤细胞的迁移和侵袭性，并在斑马鱼 A375 细胞异种移植模型中表现出强大的抗肿瘤功效。DHPS-IN-2 可用于黑色素瘤的研究。

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DHPS-IN-2

DHPS-IN-2 Chemical Structure

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DHPS-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC50 of 70 nM and a Kd of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma[1].

体外研究
(In Vitro)

DHPS-IN-2 (Compound 7C16) 可抑制 A375 和 B16 细胞增殖，IC50 分别为 4.0 和 14.4 μM，且对正常 HaCaT 细胞 (CC50 = 16.6 μM) 具有较低的细胞毒性[1]。
DHPS-IN-2 (1-10 μM) 可显著抑制 A375 细胞的侵袭和迁移能力[1]。
DHPS-IN-2 (1-10 μM, 24 h) 通过调节 A375 细胞中黑色素瘤相关蛋白 (elF5A-Hyp) 的表达来抑制黑色素瘤增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHPS-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: A375 cells
Concentration: 1, 5 and 10 μM
Incubation Time: 24 h
Result: Significantly reduced the level of eIF5A-Hyp.
Reduced the melanoma markers GP-100 and tyrosinase.
Did not affect the total expression of DHPS protein.
体内研究
(In Vivo)

DHPS-IN-2 (Compound 7C16) (15.6 μM, 7 days) 在斑马鱼异种移植模型中表现出强效的抗黑色素瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A375 cells were fluorescently labeled with CM-DiI and Xenograft via microinjection into the yolk sac of 2 dpf wild-type AB strain zebrafish[1]
Dosage: 15.6 μM
Administration: 7 days
Result: Exhibited superior antitumor efficacy at lower concentrations.
分子量

406.22

Formula

C17H15IN2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHPS-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHPS-IN-2DNA/RNA SynthesisDeoxyhypusine synthaseAllosteric inhibitors1,3,4-Oxadiazole derivativesZebrafish xenograft modelInhibitorinhibitorinhibit

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