2. Apoptosis
  3. Bcl-2 Family
  4. Dimebutic acid sodium

Dimebutic acid sodium  (Synonyms: NSC-16045 sodium; NSC-741804 sodium)

目录号: HY-W015881A
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Dimebutic acid sodium 是一种口服活性短链脂肪酸。Dimebutic acid sodium 刺激胎儿珠蛋白的产生，改变 Bcl 家族蛋白的平衡。Dimebutic acid sodium 延长红细胞存活期。Dimebutic acid sodium 在大鼠中显示毒性。Dimebutic acid sodium 可用于 β-地中海贫血和镰状细胞病的研究。

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Dimebutic acid sodium

Dimebutic acid sodium Chemical Structure

CAS No. : 3934-02-9

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Dimebutic acid sodium 的其他形式现货产品:

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Dimebutic acid sodium 相关抗体

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

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  • 参考文献

生物活性

Dimebutic acid sodium is an orally active short-chain fatty acid. Dimebutic acid sodium stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid sodium prolongs red blood cell survival. Dimebutic acid sodium exhibits toxicity in rats. Dimebutic acid sodium can be used in the study of β-thalassemia and sickle cell disease[1][2].

体内研究
(In Vivo)

Dimebutic acid (200-1000 mg/kg；口服；每日一次；最多 15 天) sodium 在高剂量 (1000 mg/kg) 下引起 Sprague-Dawley 大鼠出现共济失调和体重减轻等毒性反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male: 200-260 g, female: 160-220 g)[2]
Dosage: 200 mg/kg, 600 mg/kg, 1000 mg/kg
Administration: Oral gavage (p.o.)
Result: Did not cause mortality in any dose group.
Showed ataxia for females, had rough coat and thin appearance for males (at 1000 mg/kg).
Showed frequent functional observational battery (FOB) deficits in females, including decreased body tone, rectal temperature, etc.
Decreased RBC, HGB, HCT and increased reticulocytes at high doses.
Increased liver and kidney weights at 1000 mg/kg.
分子量

138.14

Formula

C6H11NaO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimebutic acid sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimebutic acid3934-02-9NSC-16045NSC-741804NSC16045NSC 16045NSC741804NSC 741804Bcl-2 FamilyInhibitorinhibitorinhibit

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