2. Anti-infection
  3. Influenza Virus
  4. Diridavumab

Diridavumab  (Synonyms: 地利伏单抗; CR6261)

目录号: HY-P99853 纯度: 96.54%
COA 技术支持

Diridavumab 是一种单克隆抗 HA 茎抗体。Diridavumab 可稳定融合前的 HA 结构并防止核内体中细胞膜和病毒膜的 pH 依赖性融合。Diridavumab 可用于 H2 流感病毒的研究。

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CAS No. : 1393659-46-5

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥7500
In-stock
10 mg   询价  
50 mg   询价  

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Diridavumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus[1].

同型

Human IgG1 lambda2
推荐同型对照抗体
反应种属

Virus
IC50 & Target

influenza A virus hemagglutinin HA
体外研究
(In Vitro)

Diridavumab (CR6261; 500 μg/mL) 分别以 39.4 μg/mL 和 176.8 μg/mL 的浓度中和 AA60 和 Sw06[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diridavumab 相关抗体:
体内研究
(In Vivo)

Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; 携带 H2 流感病毒的 BALB/c 小鼠) 以剂量依赖性方式保护小鼠免受致命的 H2 流感病毒的侵害[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with H2 influenza virus[1]
Dosage: 1.7, 5, or 15 mg/kg
Administration: Intraperitoneal injection
Result: Prevented mortality and decreased the percent weight loss.
Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.
Clinical Trial
Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.2 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

地利伏单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized HA/Hemagglutinin Protein, H1N1 can bind Diridavumab. The EC50 for this effect is 5.645 ng/mL.
纯度 & 产品资料

纯度: 98.09%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Diridavumab 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diridavumab1393659-46-5CR6261地利伏单抗CR 6261CR-6261Influenza VirusHApH-dependent fusioncellularviral membranesendosomeInhibitorinhibitorinhibit

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