2. Anti-infection
  3. Influenza Virus
  4. Diridavumab

Diridavumab  (Synonyms: CR6261)

目录号: HY-P99853 纯度: 98.09%
COA

摩尔计算器

Diridavumab 是一种单克隆抗 HA 茎抗体。Diridavumab 可稳定融合前的 HA 结构并防止核内体中细胞膜和病毒膜的 pH 依赖性融合。Diridavumab 可用于 H2 流感病毒的研究。

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Diridavumab Chemical Structure

Diridavumab Chemical Structure

CAS No. : 1393659-46-5

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规格 价格 是否有货 数量
1 mg ￥3500
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5 mg ￥7500
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Diridavumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus[1].

体外研究
(In Vitro)

Diridavumab (CR6261; 500 μg/mL) 分别以 39.4 μg/mL 和 176.8 μg/mL 的浓度中和 AA60 和 Sw06[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diridavumab 相关抗体:
体内研究
(In Vivo)

Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; 携带 H2 流感病毒的 BALB/c 小鼠) 以剂量依赖性方式保护小鼠免受致命的 H2 流感病毒的侵害[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with H2 influenza virus[1]
Dosage: 1.7, 5, or 15 mg/kg
Administration: Intraperitoneal injection
Result: Prevented mortality and decreased the percent weight loss.
Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diridavumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diridavumab1393659-46-5CR6261CR 6261CR-6261Influenza VirusHApH-dependent fusioncellularviral membranesendosomeInhibitorinhibitorinhibit

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