2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. DM-4107

DM-4107 是一种 Tolvaptan (HY-17000) 的主要代谢物，主要通过肝脏中的 CYP3A4 酶代谢。DM-4107 在 SCHH 细胞中抑制人体肝脏转运蛋白 NTCP、BSEP、MRP3、MRP4 (IC50 分别为 95.6、119、61.2、37.9 μM) 和胆汁酸转运的能力。DM-4107 可用于常染色体显性多囊肾病 (ADPKD) 的研究。

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DM-4107

DM-4107 Chemical Structure

CAS No. : 1346599-75-4

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DM-4107 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 μM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[1][2].

分子量

480.94

Formula

C26H25ClN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DM-4107 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM-41071346599-75-4DM4107DM 4107P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243NTCPBSEPMRP3MRP4autosomal dominant polycystic kidney disease (ADPKD)Inhibitorinhibitorinhibit

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目录号：
HY-W702908
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