2. 寡核苷酸
  3. 反义寡核苷酸
  4. Donidalorsen sodium

Donidalorsen sodium  (Synonyms: ISIS-721744; IONIS-PKK-LRX)

目录号: HY-139787A
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Donidalorsen (sodium) 是一种反义寡核苷酸，减少 prekallikrein (PKK) 的产生，PKK在与遗传性血管性水肿（HAE）急性发作相关的炎症介质的激活中起重要作用。

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DNA, d([2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]rG-sp-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-sp-G-sp-T-sp-m5C-sp-T-sp-m5C-sp-T-sp-T-sp-G-sp-G-sp-m5C-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)

Donidalorsen sodium Chemical Structure

CAS No. : 2304701-45-7

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Donidalorsen sodium 相关抗体

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生物活性

Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).

Clinical Trial
分子量

9112.16

Formula

C296H435N83Na20O151P20S15
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
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Keywords:

Donidalorsen2304701-45-7ISIS-721744 IONIS-PKK-LRXISIS721744ISIS 721744OthersInhibitorinhibitorinhibit

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