2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Dopamine Receptor Reactive Oxygen Species (ROS)
  4. Dopamine D4 receptor ligand 3

Dopamine D4 receptor ligand 3 (Compound 16) 是一种多巴胺 D4 受体 (D4R) 拮抗剂 (pKi: 8.86)。Dopamine D4 receptor ligand 3 在 HEK-293T 细胞中对 Go、Gi 和 βArr2 三种传感器的 pIC50 分别为 5.78、5.55 和 6.17。Dopamine D4 receptor ligand 3 可抑制 U87 MG、T98G 和 U251 MG 三种人胶质瘤细胞系的活性。Dopamine D4 receptor ligand 3 可诱导胶质瘤细胞中 ROS 的产生和线粒体功能障碍。

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Dopamine D4 receptor ligand 3 Chemical Structure

Dopamine D4 receptor ligand 3 Chemical Structure

CAS No. : 3082344-46-2

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生物活性

Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86). Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells[1].

分子量

489.56

Formula

C28H31N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
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  • Do most proteins show cross-species activity?

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Keywords:

Dopamine D4 receptor ligand 33082344-46-2Dopamine ReceptorReactive Oxygen Species (ROS)U87 MGT98GU251 MGglioma cellsHEK-293T cellsGoGiβArr2 sensorsanticancerInhibitorinhibitorinhibit

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