Duramycin  (Synonyms: Moli1901; Lancovutide)

Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF)^[1][2].

Evaluation of [⁶⁸Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [⁶⁸Ga]NODAGA-Duramycin. [⁶⁸Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2013.28

C₈₉H₁₂₅N₂₃O₂₅S₃

1391-36-2

固体

White to off-white

Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)

CKQCCAFGPF-{Abu}-FVCDGN-{Abu}-K-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)

Room temperature in continental US; may vary elsewhere.

• [1]. Oliynyk I, et al. Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia. APMIS. 2010 Dec;118(12):982-90.  [Content Brief]

  [2]. Huo L, et al. Insights into the Biosynthesis of Duramycin. Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02698-16.  [Content Brief]