2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Edatrexate

Edatrexate  (Synonyms: CGP 30694)

目录号: HY-13617
产品使用指南

摩尔计算器

Edatrexate (CGP 30694)，即 10-乙基-10-去甲氨基蝶呤，是甲氨蝶呤 Methotrexate (HY-14519) 的类似物，对耐 MTX 肿瘤具有抗肿瘤活性。Edatrexate 是一种抗叶酸抗代谢物，可用于研究非小细胞肺癌，乳腺癌，非霍奇金淋巴瘤和头颈部癌症的研究。

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Edatrexate Chemical Structure

Edatrexate Chemical Structure

CAS No. : 80576-83-6

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Edatrexate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck[1][2].

体内研究
(In Vivo)

Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine models of advanced metastatic disease (including E0771 mammary adenocarcinoma, T241 fibrosarcoma, Lewis lung carcinoma, B16 melanoma, or C38 colon carcinoma)[2]
Dosage: 0.14 g/kg and 0.21 g/kg
Administration: Intraperitoneal injection; 0.14 g/kg twice weekly for 3 weeks and 0.21 g/kg weekly for 3 weeks; added Ca leucovorin (LCV) 16, 20, 24 h after Edatrexate treatment
Result: Increased survival of tumor-bearing mice.
Showed markedly therapeutic effectiveness against advanced metastatic disease in high-dose regimen with delayed LCV rescue.
分子量

467.48

Formula

C22H25N7O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Edatrexate 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Edatrexate80576-83-6CGP 30694CGP30694CGP-30694AntifolatemethotrexateMTXmurine models of advanced metastatic diseaseCa leucovorinLCVInhibitorinhibitorinhibit

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