1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EGFR-IN-106

EGFR-IN-106 (compound 6) 是一种有效的 EGFR 抑制剂,IC50 值为 0.2396 µM。EGFR-IN-106 显示出细胞毒性和抗炎活性。

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EGFR-IN-106 Chemical Structure

EGFR-IN-106 Chemical Structure

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-106 (compound 6) is a potentEGFR inhibitor with an IC50 value of 0.2396 µM. EGFR-IN-106 shows cytotoxic and anti-inflammatory activity[1]

IC50 & Target[1]

EGFR

0.2396 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-106 (compound 6) (0-100 µM; 24 h) 对 AGS、A-431、MCF-7、MDA-MB-231、HaCaT 细胞具有细胞毒性,IC50 值分别为 3.64、0.034、2.67、10.51、>100 µM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AGS, A-431, MCF-7, MDA-MB-231, HaCaT cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell viability with IC50s of 3.64, 0.034, 2.67, 10.51, >100 µM for AGS, A-431, MCF-7, MDA-MB-231, HaCaT cells, respectively.
分子量

434.53

Formula

C24H30N6O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
EGFR-IN-106
目录号:
HY-162323
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