2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Epigenetics PI3K/Akt/mTOR
  3. EGFR AMPK
  4. EGFR-IN-146

EGFR-IN-146 是一种 EGFR 抑制剂，能够抑制 EGFR 信号通路，通过激活 AMPK 途径，改善胰岛素敏感性，可有效降低血糖水平和体重。EGFR-IN-146 在研究糖尿病和肥胖症中有巨大潜力。

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EGFR-IN-146 Chemical Structure

EGFR-IN-146 Chemical Structure

CAS No. : 166039-38-9

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EGFR-IN-146 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-146 is an EGFR inhibitor that can inhibit the EGFR signaling pathway and improve insulin sensitivity by activating the AMPK pathway, which can effectively reduce blood sugar levels and body weight. EGFR-IN-146 has great potential in the study of diabetes and obesity[1].

体外研究
(In Vitro)

EGFR-IN-146 (Compound 53) (10 μM) 在 C2C12 细胞模型中，有效的促进葡萄糖吸收，起到降血糖的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-146 相关抗体:
分子量

312.37

Formula

C20H16N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-146 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-146166039-38-9EGFRAMPKEpidermal growth factor receptorErbB-1HER1AMP-activated protein kinasediabetesobesityC2C12 cellsInhibitorinhibitorinhibit

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