1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. EGFR Apoptosis
  3. EGFR-IN-51

EGFR-IN-51 (Compound 6) 是一种有效的 EGFR 抑制剂,对EGFR 、EGFR L858R-TKEGFR T790M-TKIC50 值分别为 0.493、102.60 和 461.63 µM。EGFR-IN-51 对癌细胞具有毒性,诱导细胞凋亡 (apoptosis)。

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EGFR-IN-51 Chemical Structure

EGFR-IN-51 Chemical Structure

CAS No. : 2418549-32-1

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  • 生物活性

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生物活性

EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

IC50 & Target

EGFR

0.493 μM (IC50)

EGFRL858R

102.60 μM (IC50)

EGFRT790M

461.63 μM (IC50)

分子量

373.43

Formula

C21H15N3O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EGFR-IN-51
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HY-146471
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