1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. EGFR Apoptosis
  3. EGFR-IN-52

EGFR-IN-52 (Compound 4) 是一种有效的 EGFR 抑制剂,对EGFR 、EGFR L858R-TKEGFR T790M-TKIC50 值分别为 0.358、86.02 和 432.67 µM。EGFR-IN-52 对癌细胞具有毒性,诱导细胞凋亡 (apoptosis)。

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EGFR-IN-52 Chemical Structure

EGFR-IN-52 Chemical Structure

CAS No. : 454436-75-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

IC50 & Target

EGFR

0.358 μM (IC50)

EGFRL858R

86.02 μM (IC50)

EGFRT790M

432.67 μM (IC50)

分子量

382.44

Formula

C19H18N4O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
EGFR-IN-52
目录号:
HY-146472
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