2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Eicosapentaenoyl ethanolamide

Eicosapentaenoyl ethanolamide 

目录号: HY-124089 纯度: 98.38%
COA 产品使用指南 技术支持

Eicosapentaenoyl ethanolamide 是 omega-3 脂肪酸，一种 N-酰基乙醇胺 (NAE)。Eicosapentaenoyl ethanolamide 是大麻素 CB1/CB2 受体激动剂。Eicosapentaenoyl ethanolamide 是一种代谢信号。Eicosapentaenoyl ethanolamide 抑制饮食限制 (DR) 诱导的野生型动物寿命延长，并抑制 TOR 通路突变体的寿命延长。

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Eicosapentaenoyl ethanolamide

Eicosapentaenoyl ethanolamide Chemical Structure

CAS No. : 109001-03-8

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规格 价格 是否有货 数量
5 mg (144.71 mM * 100 μL in Ethanol) ￥629
In-stock
10 mg (144.71 mM * 200 μL in Ethanol) ￥978
In-stock

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Customer Review

Eicosapentaenoyl ethanolamide 相关抗体

Top Publications Citing Use of Products

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

IC50 & Target[1]

CB1

 

CB2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RBL-2H3 IC50
24 μM
Compound: 15; EPEA
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
[PMID: 31618024]
体外研究
(In Vitro)

Eicosapentaenoyl ethanolamide (EPEA) induces cell death in both LNCaP and PC3 cells (IC50=16.19 μM). EPEA (24 hours) did not result in any significant changes in the G1, S or G2 phases of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eicosapentaenoyl ethanolamide 相关抗体:
分子量

345.52

Formula

C22H35NO2
CAS 号
性状

粘稠液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (289.42 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8942 mL 14.4709 mL 28.9419 mL
5 mM 0.5788 mL 2.8942 mL 5.7884 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Eicosapentaenoyl ethanolamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8942 mL 14.4709 mL 28.9419 mL 72.3547 mL
5 mM 0.5788 mL 2.8942 mL 5.7884 mL 14.4709 mL
10 mM 0.2894 mL 1.4471 mL 2.8942 mL 7.2355 mL
15 mM 0.1929 mL 0.9647 mL 1.9295 mL 4.8236 mL
20 mM 0.1447 mL 0.7235 mL 1.4471 mL 3.6177 mL
25 mM 0.1158 mL 0.5788 mL 1.1577 mL 2.8942 mL
30 mM 0.0965 mL 0.4824 mL 0.9647 mL 2.4118 mL
40 mM 0.0724 mL 0.3618 mL 0.7235 mL 1.8089 mL
50 mM 0.0579 mL 0.2894 mL 0.5788 mL 1.4471 mL
60 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2059 mL
80 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
100 mM 0.0289 mL 0.1447 mL 0.2894 mL 0.7235 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eicosapentaenoyl ethanolamide109001-03-8Cannabinoid Receptoromega-3 fatty acidN-acylethanolamineslifespan extensionTOR pathway mutantEPEALNCaPPC3 cellsInhibitorinhibitorinhibit

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